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March 2008 Off the Wire . . .




How does Interferon Beta work in MS?

Submitted by art on Mon, 2008-04-14 08:12.

In this study, mice lacking a component of the molecule to which IFN-beta binds to mediate its effects were found to develop more severe EAE (a model of MS) than mice expressing this protein. This was associated with increased numbers of immune cells known as Th17 cells in the central nervous system of the mice.

Further experiments showed that disease could be alleviated in these mice by administration of a soluble molecule known as IL-27, leading the authors to suggest that in individuals with MS, the beneficial effects of IFN-beta are likely to be mediated, at least in part, through its ability to induce the secretion of IL-27.

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